Reactome | KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10215046] ubiquitin protein ligase activity of KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-9712276] NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 - Rattus norvegicus [Reaction:R-RNO-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10214349
displayName	KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol]
hasComponent	2 × [Complex:R-RNO-8932333] KEAP1:NEDD8-CUL3:RBX1 [cytosol] [EntityWithAccessionedSequence:R-RNO-201566] Nfe2l2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8932286] KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] - Homo sapiens
maxDepth	3
name	KEAP1:NEDD8-CUL3:RBX1:NFE2L2
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8932286
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-9712274] NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 [Reaction:R-RNO-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2
(physicalEntity)	[CatalystActivity:10215046] ubiquitin protein ligase activity of KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol]
(hasComponent)	[Complex:R-RNO-9712276] NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol]
(inferredTo)	[Complex:R-HSA-8932286] KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol]

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