Reactome | BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose

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BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose Show undefined attributes

catalystActivity	[CatalystActivity:10201544] NAD+ nucleosidase activity, cyclic ADP-ribose generating of BST1 dimer [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10201546
displayName	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose
eventOf	[Pathway:R-RNO-196807] Nicotinate metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8870346] BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-352330] NAD+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose NAD(+) + H2O => ADP-D-ribose + nicotinamide + H(+)
output	[SimpleEntity:R-ALL-8870342] ADP-ribose [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-8870343] NAM [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8870346
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-8870346] BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose

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