Reactome | Dynamin-mediated GTP hydrolysis promotes vesicle scission

Schema > Reaction > Entries

Dynamin-mediated GTP hydrolysis promotes vesicle scission Show undefined attributes

catalystActivity	[CatalystActivity:10201381] GTPase activity of PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10201383
displayName	Dynamin-mediated GTP hydrolysis promotes vesicle scission
eventOf	[Pathway:R-RNO-8856828] Clathrin-mediated endocytosis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-8868659] Clathrin recruits auxilins to the clathrin-coated vesicle - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8868661] Dynamin-mediated GTP hydrolysis promotes vesicle scission - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-RNO-8868629] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Dynamin-mediated GTP hydrolysis promotes vesicle scission
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-RNO-8868624] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-RNO-8868648] SYNJ hydrolyze PI(4,5)P2 to PI(4)P - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8868661
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-RNO-8868659] Clathrin recruits auxilins to the clathrin-coated vesicle
(inferredTo)	[Reaction:R-HSA-8868661] Dynamin-mediated GTP hydrolysis promotes vesicle scission