Reactome | LINC01139 promotes phosphorylation of HIF1A by PTK6

Schema > Reaction > Entries

LINC01139 promotes phosphorylation of HIF1A by PTK6 Show undefined attributes

catalystActivity	[CatalystActivity:10199699] protein tyrosine kinase activity of HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10199701
displayName	LINC01139 promotes phosphorylation of HIF1A by PTK6
eventOf	[Pathway:R-RNO-8857538] PTK6 promotes HIF1A stabilization - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9634702] LINC01139 promotes phosphorylation of HIF1A by LRRK2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8857583] LINC01139 promotes phosphorylation of HIF1A by PTK6 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-RNO-1234102] Hif1a [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LINC01139 promotes phosphorylation of HIF1A by PTK6
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-8857584] phospho-Hif1a [cytosol]
precedingEvent	[Reaction:R-RNO-8857577] LINC01139 facilitates PTK6 autophosphorylation - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8857583
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8857538] PTK6 promotes HIF1A stabilization
(precedingEvent)	[Reaction:R-RNO-9634702] LINC01139 promotes phosphorylation of HIF1A by LRRK2
(inferredTo)	[Reaction:R-HSA-8857583] LINC01139 promotes phosphorylation of HIF1A by PTK6

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