Reactome | SCF:FBXL7 binds AURKA

Schema > Reaction > Entries

SCF:FBXL7 binds AURKA Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10198935
displayName	SCF:FBXL7 binds AURKA
eventOf	[Pathway:R-RNO-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-8854041] SCF-FBXL7 ubiquitinates AURKA - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:422949] negative regulation of G2/M transition of mitotic cell cycle
inferredFrom	[Reaction:R-HSA-8853496] SCF:FBXL7 binds AURKA - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-174254] AURKA [cytosol] [Complex:R-RNO-8854030] SKP1:CUL1:RBX1:FBXL7 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SCF:FBXL7 binds AURKA
output	[Complex:R-RNO-8854031] SCF-FBXL7:AURKA [cytosol]
precedingEvent	[Reaction:R-RNO-8854052] Formation of the SCF-FBXL7 complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8853496
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
(precedingEvent)	[Reaction:R-RNO-8854041] SCF-FBXL7 ubiquitinates AURKA
(inferredTo)	[Reaction:R-HSA-8853496] SCF:FBXL7 binds AURKA