Reactome | PHLDA1 binds AURKA

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10198923
displayName	PHLDA1 binds AURKA
eventOf	[Pathway:R-RNO-8854521] Interaction between PHLDA1 and AURKA - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-8853444] AURKA phosphorylates PHLDA1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8853429] PHLDA1 binds AURKA - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-174254] AURKA [cytosol] [EntityWithAccessionedSequence:R-RNO-8853431] Phlda1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PHLDA1 binds AURKA
output	[Complex:R-RNO-8853432] AURKA:PHLDA1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8853429
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-8854521] Interaction between PHLDA1 and AURKA
(precedingEvent)	[Reaction:R-RNO-8853444] AURKA phosphorylates PHLDA1
(inferredTo)	[Reaction:R-HSA-8853429] PHLDA1 binds AURKA

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