Reactome | PREX2 binds PTEN and inhibits it

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10198249
displayName	PREX2 binds PTEN and inhibits it
eventOf	[Pathway:R-RNO-8948751] Regulation of PTEN stability and activity - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8850961] PREX2 binds PTEN and inhibits it - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-8850949] Prex2 [cytosol] [DefinedSet:R-RNO-8850937] PTEN, p-3S,2T-PTEN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PREX2 binds PTEN and inhibits it
output	[Complex:R-RNO-8850934] PREX2:PTEN,p-3S,2T-PTEN [cytosol]
precedingEvent	[Reaction:R-RNO-8850945] Casein kinase II phosphorylates PTEN - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8850961
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-8948751] Regulation of PTEN stability and activity
(inferredTo)	[Reaction:R-HSA-8850961] PREX2 binds PTEN and inhibits it

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