Reactome | ERBB2 promotes PTK6 autophosphorylation

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ERBB2 promotes PTK6 autophosphorylation Show undefined attributes

catalystActivity	[CatalystActivity:10197382] protein tyrosine kinase activity of p-ERBB2 heterodimers:PTK6 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10197384
displayName	ERBB2 promotes PTK6 autophosphorylation
eventOf	[Pathway:R-RNO-8847993] ERBB2 Activates PTK6 Signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-8849428] PTPN1 binds PTK6 - Rattus norvegicus [Reaction:R-RNO-8848110] SOCS3 binds activated PTK6 - Rattus norvegicus [Reaction:R-RNO-8848023] Activated PTK6 binds STAP2 - Rattus norvegicus [Reaction:R-RNO-8848818] PTK6 phosphorylates CBL - Rattus norvegicus [Reaction:R-RNO-8848751] PTK6 binds AKT1 - Rattus norvegicus [Reaction:R-RNO-8848864] PTK6 binds ARAP1 - Rattus norvegicus [Reaction:R-RNO-8848774] PTK6 binds DOK1 - Rattus norvegicus [Reaction:R-RNO-8848930] PTK6 translocates to the nucleus - Rattus norvegicus [Reaction:R-RNO-8849055] PTK6 binds ARHGAP35 - Rattus norvegicus [Reaction:R-RNO-8848713] PTK6 binds BCAR1 - Rattus norvegicus [Reaction:R-RNO-8848596] PTK6 binds PXN - Rattus norvegicus [Reaction:R-RNO-8848414] Activated PTK6 binds CDKN1B - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8848005] ERBB2 promotes PTK6 autophosphorylation - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-8848002] p-ERBB2 heterodimers:PTK6 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ERBB2 promotes PTK6 autophosphorylation
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [CandidateSet:R-RNO-1963588] p-ERBB2 heterodimers [plasma membrane] [EntityWithAccessionedSequence:R-RNO-8848007] phospho-Ptk6 [cytosol]
precedingEvent	[Reaction:R-RNO-8847995] Activated ERBB2 binds PTK6 (BRK) - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8848005
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-8849428] PTPN1 binds PTK6 [Reaction:R-RNO-8848110] SOCS3 binds activated PTK6 [Reaction:R-RNO-8848023] Activated PTK6 binds STAP2 [Reaction:R-RNO-8848818] PTK6 phosphorylates CBL [Reaction:R-RNO-8848751] PTK6 binds AKT1 [Reaction:R-RNO-8848864] PTK6 binds ARAP1 [Reaction:R-RNO-8848774] PTK6 binds DOK1 [Reaction:R-RNO-8848930] PTK6 translocates to the nucleus [Reaction:R-RNO-8849055] PTK6 binds ARHGAP35 [Reaction:R-RNO-8848713] PTK6 binds BCAR1 [Reaction:R-RNO-8848596] PTK6 binds PXN [Reaction:R-RNO-8848414] Activated PTK6 binds CDKN1B
(hasEvent)	[Pathway:R-RNO-8847993] ERBB2 Activates PTK6 Signaling
(inferredTo)	[Reaction:R-HSA-8848005] ERBB2 promotes PTK6 autophosphorylation

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