Reactome | PTEN binds FRK

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10197364
displayName	PTEN binds FRK
eventOf	[Pathway:R-RNO-8948751] Regulation of PTEN stability and activity - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-8847977] FRK phosphorylates PTEN - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8847968] PTEN binds FRK - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-8847965] phospho-p-Y387-FRK [cytosol] [EntityWithAccessionedSequence:R-RNO-199420] Pten [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTEN binds FRK
output	[Complex:R-RNO-8847960] PTEN:p-Y387-FRK [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8847968
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-8948751] Regulation of PTEN stability and activity
(precedingEvent)	[Reaction:R-RNO-8847977] FRK phosphorylates PTEN
(inferredTo)	[Reaction:R-HSA-8847968] PTEN binds FRK