Reactome | RNA Polymerase II Transcription Initiation

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RNA Polymerase II Transcription Initiation Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222287
displayName	RNA Polymerase II Transcription Initiation
eventOf	[Pathway:R-RNO-76042] RNA Polymerase II Transcription Initiation And Promoter Clearance - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:17841] transcription initiation at RNA polymerase II promoter
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-75861] NTP Binds Active Site of RNA Polymerase II - Rattus norvegicus [Reaction:R-RNO-75866] Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP - Rattus norvegicus [Reaction:R-RNO-75864] Newly Formed Phosphodiester Bond Stabilized and PPi Released - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-75953] RNA Polymerase II Transcription Initiation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RNA Polymerase II Transcription Initiation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-75953
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-76042] RNA Polymerase II Transcription Initiation And Promoter Clearance
(inferredTo)	[Pathway:R-HSA-75953] RNA Polymerase II Transcription Initiation

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