Reactome | PP2A dephosphorylates p-RHO to RHO

Schema > Reaction > Entries

PP2A dephosphorylates p-RHO to RHO Show undefined attributes

catalystActivity	[CatalystActivity:10108745] protein serine/threonine phosphatase activity of PPEF1:Mg2+ [cytosol]
category	transition
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10108759
displayName	PP2A dephosphorylates p-RHO to RHO
eventOf	[Pathway:R-RNO-2514859] Inactivation, recovery and regulation of the phototransduction cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2454118] 11cRAL binds to opsin to form 11c-retinyl:RHO - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-74948] PP2A dephosphorylates p-RHO to RHO - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-RNO-2581504] phospho-p-S334,338,343-RHO [photoreceptor disc membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PP2A dephosphorylates p-RHO to RHO
output	3 × [SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-RNO-419802] RHO [photoreceptor disc membrane]
regulatedBy	[PositiveRegulation:R-HSA-71589] Positive regulation by 'Ca2+ [cytosol]' [NegativeRegulation:10108760] Negative regulation by 'p-MII:SAG [photoreceptor disc membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74948
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2514859] Inactivation, recovery and regulation of the phototransduction cascade
(precedingEvent)	[Reaction:R-RNO-2454118] 11cRAL binds to opsin to form 11c-retinyl:RHO
(inferredTo)	[Reaction:R-HSA-74948] PP2A dephosphorylates p-RHO to RHO