Reactome | CALM1:4xCa2+ [cytosol]

Schema > Complex > Entries

CALM1:4xCa2+ [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-9619357] p-CaMKK:CALM1:4xCa2+ [cytosol] - Rattus norvegicus [Complex:R-RNO-3229184] CALM1:Ca2+:CNG channel [plasma membrane] - Rattus norvegicus [Complex:R-RNO-202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-3229181] CALM1:Ca2+ binds CNG channel - Rattus norvegicus [Reaction:R-RNO-202110] eNOS:Caveolin-1 complex binds to CaM - Rattus norvegicus [Reaction:R-RNO-202110] eNOS:Caveolin-1 complex binds to CaM - Rattus norvegicus [Reaction:R-RNO-9619376] CAMK1 binds calmodulin - Rattus norvegicus [Reaction:R-RNO-445797] MYLK (MLCK) Active Calmodulin Binding - Rattus norvegicus [Reaction:R-RNO-2730872] Activation of Calcineurin - Rattus norvegicus [Reaction:R-RNO-4332359] Active calmodulin binds CAMK2 - Rattus norvegicus [Reaction:R-RNO-9653585] S-Farn-Me KRAS4B binds calmodulin - Rattus norvegicus [Reaction:R-RNO-111966] GRK2 binds CALM1:4Ca2+ - Rattus norvegicus [Reaction:R-RNO-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Rattus norvegicus [Reaction:R-RNO-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Rattus norvegicus [Reaction:R-RNO-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Rattus norvegicus [Reaction:R-RNO-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Rattus norvegicus [Reaction:R-RNO-2025890] Calcineurin binds NFATC1,2,3 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10112128
displayName	CALM1:4xCa2+ [cytosol]
hasComponent	4 × [SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [EntityWithAccessionedSequence:R-RNO-9016707] CALM1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-74294] CALM1:4xCa2+ [cytosol] - Homo sapiens
maxDepth	2
name	CALM1:4xCa2+
positivelyRegulates	[PositiveRegulation:10112131] Positive regulation by 'CALM1:4xCa2+ [cytosol]'
producedByEvent	[Reaction:R-RNO-202129] HSP90 binds eNOS:Caveolin-1:CaM complex - Rattus norvegicus [Reaction:R-RNO-4332358] Dissociation of CaM and CAMK2 autophosphorylation - Rattus norvegicus [BlackBoxEvent:R-RNO-9654533] KRAS4B recycles to the plasma membrane - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74294
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-RNO-3229181] CALM1:Ca2+ binds CNG channel [Reaction:R-RNO-202110] eNOS:Caveolin-1 complex binds to CaM [Reaction:R-RNO-9619376] CAMK1 binds calmodulin [Reaction:R-RNO-445797] MYLK (MLCK) Active Calmodulin Binding [Reaction:R-RNO-2025890] Calcineurin binds NFATC1,2,3 [Reaction:R-RNO-2730872] Activation of Calcineurin [Reaction:R-RNO-4332359] Active calmodulin binds CAMK2 [Reaction:R-RNO-9653585] S-Farn-Me KRAS4B binds calmodulin [Reaction:R-RNO-111966] GRK2 binds CALM1:4Ca2+ [Reaction:R-RNO-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)
(hasComponent)	[Complex:R-RNO-3229184] CALM1:Ca2+:CNG channel [plasma membrane] [Complex:R-RNO-444601] CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] [Complex:R-RNO-202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] [Complex:R-RNO-1497889] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] [Complex:R-RNO-9619374] CAMK1:CALM1:4xCa2+ [cytosol] [Complex:R-RNO-9619357] p-CaMKK:CALM1:4xCa2+ [cytosol] [Complex:R-RNO-9619230] CaMKK:CALM1:4xCa2+ [cytosol] [Complex:R-RNO-445764] MYLK:Ca2+:CALM1 [cytosol] [Complex:R-RNO-2026003] PPP3CA,B:Calmodulin [cytosol] [Complex:R-RNO-4332345] CAMK2:CaM [cytosol] [Complex:R-RNO-4332348] p-T286 CAMK2:CaM [cytosol] [Complex:R-RNO-9653583] S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane] [Complex:R-RNO-9654512] S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol] [Complex:R-RNO-111965] GRK2:CALM1:4xCa2+ [plasma membrane] [Complex:R-RNO-9865674] TRPV4 tetramer:CALM1:Ca2+ [plasma membrane] [Complex:R-RNO-442735] Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] [Complex:R-RNO-9617582] p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol]
(output)	[Reaction:R-RNO-202129] HSP90 binds eNOS:Caveolin-1:CaM complex [Reaction:R-RNO-4332358] Dissociation of CaM and CAMK2 autophosphorylation [BlackBoxEvent:R-RNO-9654533] KRAS4B recycles to the plasma membrane
(regulator)	[PositiveRegulation:10112131] Positive regulation by 'CALM1:4xCa2+ [cytosol]'
(inferredTo)	[Complex:R-HSA-74294] CALM1:4xCa2+ [cytosol]

© 2026 Reactome

Cite Us!