Reactome | 60S ribosomal complex [cytosol]

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60S ribosomal complex [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-9948416] VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] - Rattus norvegicus [Complex:R-RNO-9948361] LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-156826] Dissociation of L13a from the 60s ribosomal subunit - Rattus norvegicus [Reaction:R-RNO-72672] The 60S subunit joins the translation initiation complex - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10107120
displayName	60S ribosomal complex [cytosol]
hasComponent	[GenomeEncodedEntity:R-RNO-72498] Ghost homologue of 28S rRNA [cytosol] [GenomeEncodedEntity:R-RNO-72496] Ghost homologue of 5.8S rRNA [cytosol] [GenomeEncodedEntity:R-RNO-72494] Ghost homologue of 5S rRNA [cytosol] [GenomeEncodedEntity:R-RNO-72468] Ghost homologue of RPL37A [cytosol] [GenomeEncodedEntity:R-RNO-72478] Ghost homologue of RPL41 [cytosol] [DefinedSet:R-RNO-72408-3] Homologues of RPL12 [cytosol] [DefinedSet:R-RNO-72446-4] Homologues of RPL29 [cytosol] [DefinedSet:R-RNO-72454-3] Homologues of RPL31 [cytosol] [DefinedSet:R-RNO-72462-3] Homologues of RPL35A [cytosol] [DefinedSet:R-RNO-72464-4] Homologues of RPL36 [cytosol] [DefinedSet:R-RNO-72466-3] Homologues of RPL37 [cytosol] [DefinedSet:R-RNO-72488-3] Homologues of RPL7A [cytosol] [DefinedSet:R-RNO-72492-3] Homologues of RPL9 [cytosol] [EntityWithAccessionedSequence:R-RNO-72426] LOC134480579 [cytosol] [CandidateSet:R-RNO-8868854] RPL10,RPL10L [cytosol] [EntityWithAccessionedSequence:R-RNO-72404] Rpl10a [cytosol] [EntityWithAccessionedSequence:R-RNO-72406] Rpl11 [cytosol] [EntityWithAccessionedSequence:R-RNO-72410] Rpl13 [cytosol] [EntityWithAccessionedSequence:R-RNO-72412] Rpl13a [cytosol] [EntityWithAccessionedSequence:R-RNO-72414] Rpl14 [cytosol] [EntityWithAccessionedSequence:R-RNO-72416] Rpl15 [cytosol] [EntityWithAccessionedSequence:R-RNO-72418] Rpl17 [cytosol] [EntityWithAccessionedSequence:R-RNO-72420] Rpl18 [cytosol] [EntityWithAccessionedSequence:R-RNO-72422] Rpl18a [cytosol] [EntityWithAccessionedSequence:R-RNO-72424] Rpl19 [cytosol] [CandidateSet:R-RNO-8868847] RPL22,RPL22L1 [cytosol] [EntityWithAccessionedSequence:R-RNO-72430] Rpl23 [cytosol] [EntityWithAccessionedSequence:R-RNO-72432] Rpl23a [cytosol] [EntityWithAccessionedSequence:R-RNO-72434] Rpl24 [cytosol] [EntityWithAccessionedSequence:R-RNO-72436] Rpl26 [cytosol] [EntityWithAccessionedSequence:R-RNO-72440] Rpl27 [cytosol] [EntityWithAccessionedSequence:R-RNO-72442] Rpl27a [cytosol] [EntityWithAccessionedSequence:R-RNO-72444] Rpl28 [cytosol] [CandidateSet:R-RNO-8868851] RPL3,RPL3L [cytosol] [EntityWithAccessionedSequence:R-RNO-5359041] Rpl30 [cytosol] [EntityWithAccessionedSequence:R-RNO-72456] Rpl32 [cytosol] [EntityWithAccessionedSequence:R-RNO-72458] Rpl34 [cytosol] [EntityWithAccessionedSequence:R-RNO-72460] Rpl35 [cytosol] [CandidateSet:R-RNO-8868819] RPL36A,RPL36AL [cytosol] [EntityWithAccessionedSequence:R-RNO-72470] Rpl38 [cytosol] [CandidateSet:R-RNO-8868812] RPL39,RPL39L [cytosol] [EntityWithAccessionedSequence:R-RNO-72474] Rpl4 [cytosol] [EntityWithAccessionedSequence:R-RNO-72482] Rpl5 [cytosol] [EntityWithAccessionedSequence:R-RNO-72484] Rpl6 [cytosol] [EntityWithAccessionedSequence:R-RNO-72486] Rpl7 [cytosol] [EntityWithAccessionedSequence:R-RNO-72490] Rpl8 [cytosol] [EntityWithAccessionedSequence:R-RNO-72396] Rplp0 [cytosol] [EntityWithAccessionedSequence:R-RNO-72398] Rplp1 [cytosol] [EntityWithAccessionedSequence:R-RNO-72400] Rplp2 [cytosol] [EntityWithAccessionedSequence:R-RNO-72476] Ubc [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-72499] 60S ribosomal complex [cytosol] - Homo sapiens
maxDepth	4
name	60S ribosomal complex
producedByEvent	[BlackBoxEvent:R-RNO-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Rattus norvegicus [Reaction:R-RNO-72673] Release of 40S and 60S subunits from the 80S ribosome - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-72499
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-RNO-9948416] VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] [Complex:R-RNO-9948361] LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala [cytosol] [Complex:R-RNO-9948294] 60S ribosomal subunit:peptidyl-tRNA with nascent peptide [cytosol] [Complex:R-RNO-9948303] K63polyUb-80S ribosome [cytosol] [Complex:R-RNO-9948455] LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol] [Complex:R-RNO-9948357] NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide [cytosol] [Complex:R-RNO-9948304] NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala [cytosol] [Complex:R-RNO-72500] 80S ribosome [cytosol]
(input)	[Reaction:R-RNO-156826] Dissociation of L13a from the 60s ribosomal subunit [Reaction:R-RNO-72672] The 60S subunit joins the translation initiation complex
(output)	[BlackBoxEvent:R-RNO-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA [Reaction:R-RNO-72673] Release of 40S and 60S subunits from the 80S ribosome
(inferredTo)	[Complex:R-HSA-72499] 60S ribosomal complex [cytosol]

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