Reactome | TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA

Schema > Reaction > Entries

TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA Show undefined attributes

catalystActivity	[CatalystActivity:9982382] trimethyllysine dioxygenase activity of TMLHE:AscH-:Fe2+ dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	9982384
displayName	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA
eventOf	[Pathway:R-RNO-71262] Carnitine synthesis - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-71241] TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix] [SimpleEntity:R-ALL-35139] TMLYS [mitochondrial matrix]
isInDisease	false
isInferred	true
name	TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 => (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate trimethyllysine + alpha-ketoglutarate + O2 => beta-hydroxy-trimethyllysine + succinate + CO2
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113546] HTMLYS [mitochondrial matrix] [SimpleEntity:R-ALL-113536] SUCCA [mitochondrial matrix]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-71241
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-71262] Carnitine synthesis
(inferredTo)	[Reaction:R-HSA-71241] TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA

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