Reactome | 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O

Schema > Reaction > Entries

4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O Show undefined attributes

catalystActivity	[CatalystActivity:10105237] 4-alpha-hydroxytetrahydrobiopterin dehydratase activity of PCBD1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10105239
displayName	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O
eventOf	[Pathway:R-RNO-8964208] Phenylalanine metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-71146] 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O - Homo sapiens
input	[SimpleEntity:R-ALL-71112] 4aOH-BH4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-71129] qDHB [cytosol]
precedingEvent	[Reaction:R-RNO-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-71146
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8964208] Phenylalanine metabolism
(precedingEvent)	[Reaction:R-RNO-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
(inferredTo)	[Reaction:R-HSA-71146] 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O

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