Reactome | HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]

Schema > Complex > Entries

HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-RNO-8876357] HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] - Rattus norvegicus [Complex:R-RNO-8876350] HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-6807008] PTPRJ dephosphorylates MET - Rattus norvegicus [Reaction:R-RNO-6807027] PTPN1 and PTPN2 dephosphorylate MET - Rattus norvegicus [Reaction:R-RNO-8851866] MET binds RANBP10 - Rattus norvegicus [Reaction:R-RNO-8875523] MET binds TNS3 - Rattus norvegicus [Reaction:R-RNO-8851919] Activated MET binds GAB1 and GRB2 - Rattus norvegicus [Reaction:R-RNO-8851908] Activated MET binds GAB1 - Rattus norvegicus [Reaction:R-RNO-8875816] STAT3 binds activated MET receptor - Rattus norvegicus [Reaction:R-RNO-8851888] MET binds SHC1-2 - Rattus norvegicus [Reaction:R-RNO-8851804] Activated MET recruits GRB2-1:SOS1 - Rattus norvegicus [Reaction:R-RNO-8851859] Activated MET binds RANBP9 and SOS1 - Rattus norvegicus [Reaction:R-RNO-8851842] MUC20 binds MET and inhibits GRB2 binding - Rattus norvegicus [Reaction:R-RNO-8875531] MET binds TNS4 - Rattus norvegicus [Reaction:R-RNO-8874079] PTK2 binds activated MET - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10165855
displayName	HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]
hasComponent	2 × [Complex:R-RNO-6806975] HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-6806977] HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] - Homo sapiens
maxDepth	4
memberOf	[CandidateSet:R-RNO-8874682] HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane] - Rattus norvegicus
name	HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer
producedByEvent	[BlackBoxEvent:R-RNO-8875659] RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane - Rattus norvegicus [Reaction:R-RNO-8875817] MET phosphorylates STAT3 - Rattus norvegicus [Reaction:R-RNO-6806974] MET dimers autophosphorylate - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6806977
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[BlackBoxEvent:R-RNO-8875659] RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane [Reaction:R-RNO-8875817] MET phosphorylates STAT3 [Reaction:R-RNO-6806974] MET dimers autophosphorylate
(input)	[Reaction:R-RNO-6807008] PTPRJ dephosphorylates MET [Reaction:R-RNO-6807027] PTPN1 and PTPN2 dephosphorylate MET [Reaction:R-RNO-8851866] MET binds RANBP10 [Reaction:R-RNO-8851842] MUC20 binds MET and inhibits GRB2 binding [Reaction:R-RNO-8875531] MET binds TNS4 [Reaction:R-RNO-8875523] MET binds TNS3 [Reaction:R-RNO-8851919] Activated MET binds GAB1 and GRB2 [Reaction:R-RNO-8851908] Activated MET binds GAB1 [Reaction:R-RNO-8874079] PTK2 binds activated MET [Reaction:R-RNO-8875816] STAT3 binds activated MET receptor [Reaction:R-RNO-8851888] MET binds SHC1-2 [Reaction:R-RNO-8851804] Activated MET recruits GRB2-1:SOS1 [Reaction:R-RNO-8851859] Activated MET binds RANBP9 and SOS1
(hasComponent)	[Complex:R-RNO-8876357] HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] [Complex:R-RNO-8876358] HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] [Complex:R-RNO-8876350] HGF:p-Y1003,4Y-MET dimer:CBL [plasma membrane] [Complex:R-RNO-8875527] HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane] [Complex:R-RNO-8875512] HGF:p-4Y-MET dimer:TNS3 [plasma membrane] [Complex:R-RNO-8851913] HGF:p-4Y-MET dimer:GAB1 [plasma membrane] [Complex:R-RNO-8851921] HGF:p-4Y-MET dimer:GRB2-1:GAB1 [plasma membrane] [Complex:R-RNO-8874609] HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2 [plasma membrane] [Complex:R-RNO-8874088] HGF:p-4Y-MET dimer:PTK2 [plasma membrane] [Complex:R-RNO-8874599] HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2 [plasma membrane] [Complex:R-RNO-8874094] HGF:p-4Y-MET dimer:p-Y397-PTK2 [plasma membrane] [Complex:R-RNO-8875815] HGF:p-4Y-MET dimer:STAT3 [plasma membrane] [Complex:R-RNO-8851882] HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] [Complex:R-RNO-8851839] HGF:p-4Y MET dimer:MUC20 [plasma membrane] [Complex:R-RNO-8851868] HGF:p-4Y-MET dimer:RANBP10 [plasma membrane] [Complex:R-RNO-8851891] HGF:p-4Y-MET dimer:p-Y317-SHC1-2 [plasma membrane] [Complex:R-RNO-8851807] HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] [Complex:R-RNO-8851860] HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] [Complex:R-RNO-8851941] HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] [Complex:R-RNO-8851942] HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane]
(hasMember)	[CandidateSet:R-RNO-8874682] HGF:p-4Y-MET dimer,(HGF:p-Y1003,4Y-METdimer) [plasma membrane]
(activeUnit)	[CatalystActivity:10198478] protein tyrosine kinase activity of HGF:p-4Y-MET dimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1 [plasma membrane] [CatalystActivity:10202131] protein tyrosine kinase activity of HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] [CatalystActivity:10202520] protein tyrosine kinase activity of HGF:p-4Y-MET dimer:STAT3 [plasma membrane] [CatalystActivity:10198460] protein tyrosine kinase activity of HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane]
(inferredTo)	[Complex:R-HSA-6806977] HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane]

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