Reactome | PDPK1 phosphorylates SGK1

Schema > Reaction > Entries

PDPK1 phosphorylates SGK1 Show undefined attributes

catalystActivity	[CatalystActivity:10111309] protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10190183
displayName	PDPK1 phosphorylates SGK1
eventOf	[Pathway:R-RNO-6804757] Regulation of TP53 Degradation - Rattus norvegicus [Pathway:R-RNO-1257604] PIP3 activates AKT signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-6795460] SGK1 phosphorylates MDM2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6795473] PDPK1 phosphorylates SGK1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-RNO-6795313] phospho-p-S422-SGK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PDPK1 phosphorylates SGK1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-6795449] phospho-p-T256,S422-SGK1 [cytosol]
precedingEvent	[Reaction:R-RNO-6795290] mTORC2 phosphorylates SGK1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6795473
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6804757] Regulation of TP53 Degradation [Pathway:R-RNO-1257604] PIP3 activates AKT signaling
(precedingEvent)	[Reaction:R-RNO-6795460] SGK1 phosphorylates MDM2
(inferredTo)	[Reaction:R-HSA-6795473] PDPK1 phosphorylates SGK1