Reactome | GMDS dehydrates GDP-Man to GDP-DHDMan

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GMDS dehydrates GDP-Man to GDP-DHDMan Show undefined attributes

catalystActivity	[CatalystActivity:10189109] GDP-mannose 4,6-dehydratase activity of GMDS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10189111
displayName	GMDS dehydrates GDP-Man to GDP-DHDMan
eventOf	[Pathway:R-RNO-6787639] GDP-fucose biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-6787623] GFUS dimer epimerises GDP-DHDMan to GDP-KDGal - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6787632] GMDS dehydrates GDP-Man to GDP-DHDMan - Homo sapiens
input	[SimpleEntity:R-ALL-162860] GDP-Man [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GMDS dehydrates GDP-Man to GDP-DHDMan GDP-alpha-D-mannose => GDP-4-dehydro-alpha-D-rhamnose + H2O
output	[SimpleEntity:R-ALL-6787618] GDP-DHDMan [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6787632
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6787639] GDP-fucose biosynthesis
(precedingEvent)	[Reaction:R-RNO-6787623] GFUS dimer epimerises GDP-DHDMan to GDP-KDGal
(inferredTo)	[Reaction:R-HSA-6787632] GMDS dehydrates GDP-Man to GDP-DHDMan

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