Reactome | CARNS1 transforms ATP, L-His, b-Ala to CARN

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CARNS1 transforms ATP, L-His, b-Ala to CARN Show undefined attributes

catalystActivity	[CatalystActivity:10189016] carnosine synthase activity of CARNS1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10189018
displayName	CARNS1 transforms ATP, L-His, b-Ala to CARN
eventOf	[Pathway:R-RNO-70921] Histidine catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-8876789] CARNMT1 methylates CARN to Anserine - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6786245] CARNS1 transforms ATP, L-His, b-Ala to CARN - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-73590] b-Ala [cytosol] [SimpleEntity:R-ALL-29612] L-His [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CARNS1 transforms ATP, L-His, b-Ala to CARN ATP + beta-alanine + L-histidine => ADP + carnosine + H(+) + phosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-6786250] CARN [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6786245
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-8876789] CARNMT1 methylates CARN to Anserine
(hasEvent)	[Pathway:R-RNO-70921] Histidine catabolism
(inferredTo)	[Reaction:R-HSA-6786245] CARNS1 transforms ATP, L-His, b-Ala to CARN

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