Reactome | TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains

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TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains Show undefined attributes

catalystActivity	[CatalystActivity:10186261] ubiquitin-protein transferase activity of TAX1BP1:TNFAIP3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10186263
displayName	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
eventOf	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5693108] TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains - Homo sapiens
input	[Polymer:R-RNO-912740] K48polyUb [cytosol] [DefinedSet:R-RNO-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
output	[Complex:R-RNO-5693113] K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5693108
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling
(inferredTo)	[Reaction:R-HSA-5693108] TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains

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