Reactome | MRN recruits LIG3:XRCC1 to MMEJ sites

Schema > Reaction > Entries

MRN recruits LIG3:XRCC1 to MMEJ sites Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10184510
displayName	MRN recruits LIG3:XRCC1 to MMEJ sites
eventOf	[Pathway:R-RNO-5685939] HDR through MMEJ (alt-NHEJ) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5687675] LIG3 ligates remaining SSBs in MMEJ - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5687673] MRN recruits LIG3:XRCC1 to MMEJ sites - Homo sapiens
input	[Complex:R-RNO-5687663] Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] [Complex:R-RNO-110338] LIG3:XRCC1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MRN recruits LIG3:XRCC1 to MMEJ sites
output	[Complex:R-RNO-5687677] Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-5687664] FEN1 cleaves displaced ssDNA flaps during MMEJ - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5687673
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5685939] HDR through MMEJ (alt-NHEJ)
(precedingEvent)	[Reaction:R-RNO-5687675] LIG3 ligates remaining SSBs in MMEJ
(inferredTo)	[Reaction:R-HSA-5687673] MRN recruits LIG3:XRCC1 to MMEJ sites

Cite Us!