Reactome | GRB2-1:SOS1 binds p-3Y-SHC1

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GRB2-1:SOS1 binds p-3Y-SHC1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10184045
displayName	GRB2-1:SOS1 binds p-3Y-SHC1
eventOf	[Pathway:R-RNO-2428933] SHC-related events triggered by IGF1R - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5686073] GRB2-1:SOS1 binds p-3Y-SHC1 - Homo sapiens
input	[Complex:R-RNO-109797] GRB2-1:SOS1 [cytosol] [EntityWithAccessionedSequence:R-RNO-912321] phospho-Shc1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GRB2-1:SOS1 binds p-3Y-SHC1
output	[Complex:R-RNO-5686070] GRB2-1:SOS1:p-3Y-SHC1 [cytosol]
precedingEvent	[Reaction:R-RNO-109813] GRB2-1 binds SOS1 - Rattus norvegicus [Reaction:R-RNO-5686072] p-3Y-SHC1 dissociates from IGF1R - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5686073
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2428933] SHC-related events triggered by IGF1R
(inferredTo)	[Reaction:R-HSA-5686073] GRB2-1:SOS1 binds p-3Y-SHC1

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