Reactome | MRN complex binds shortened telomeres

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MRN complex binds shortened telomeres Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10183198
displayName	MRN complex binds shortened telomeres
eventOf	[Pathway:R-RNO-2559586] DNA Damage/Telomere Stress Induced Senescence - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5682018] MRN complex bound to shortened telomeres recruits ATM - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5682020] MRN complex binds shortened telomeres - Homo sapiens
input	[Complex:R-RNO-75164] MRN [nucleoplasm] [OtherEntity:R-ALL-3785706] Shortened telomere [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MRN complex binds shortened telomeres
output	[Complex:R-RNO-5682022] Shortened telomere:MRN [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-RNO-3785711] Telomere shortening during replicative exhaustion - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5682020
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2559586] DNA Damage/Telomere Stress Induced Senescence
(precedingEvent)	[Reaction:R-RNO-5682018] MRN complex bound to shortened telomeres recruits ATM
(inferredTo)	[Reaction:R-HSA-5682020] MRN complex binds shortened telomeres

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