Reactome | PEA15 binds MAPK monomers and dimers

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PEA15 binds MAPK monomers and dimers Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10182685
displayName	PEA15 binds MAPK monomers and dimers
eventOf	[Pathway:R-RNO-112409] RAF-independent MAPK1/3 activation - Rattus norvegicus [Pathway:R-RNO-5673001] RAF/MAP kinase cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5675206] PEA15 binds MAPK monomers and dimers - Homo sapiens
input	[DefinedSet:R-RNO-5674340] p-T,Y MAPK monomers and dimers [cytosol] [EntityWithAccessionedSequence:R-RNO-5675204] Pea15 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PEA15 binds MAPK monomers and dimers
output	[Complex:R-RNO-5675205] p-T,Y MAPK monomers and dimers:PEA15 [cytosol]
precedingEvent	[Reaction:R-RNO-5674385] p-T,Y MAPKs dimerize - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5675206
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5673001] RAF/MAP kinase cascade [Pathway:R-RNO-112409] RAF-independent MAPK1/3 activation
(inferredTo)	[Reaction:R-HSA-5675206] PEA15 binds MAPK monomers and dimers

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