Reactome | AMPK (complex) phosphorylates ULK1 (complex)

Schema > Reaction > Entries

AMPK (complex) phosphorylates ULK1 (complex) Show undefined attributes

catalystActivity	[CatalystActivity:10181649] protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181651
displayName	AMPK (complex) phosphorylates ULK1 (complex)
eventOf	[Pathway:R-RNO-1632852] Macroautophagy - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-5672008] Thr-180 of ULK1 is phosphorylated - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5665868] AMPK (complex) phosphorylates ULK1 (complex) - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-5672141] p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AMPK (complex) phosphorylates ULK1 (complex)
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-5673748] p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol]
precedingEvent	[Reaction:R-RNO-5672011] p-AMPK:AMP binds the ULK complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5665868
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1632852] Macroautophagy
(precedingEvent)	[BlackBoxEvent:R-RNO-5672008] Thr-180 of ULK1 is phosphorylated
(inferredTo)	[Reaction:R-HSA-5665868] AMPK (complex) phosphorylates ULK1 (complex)

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