Reactome | Activated FGFR1 phosphorylates FRS2

Schema > Reaction > Entries

Activated FGFR1 phosphorylates FRS2 Show undefined attributes

catalystActivity	[CatalystActivity:10180899] protein tyrosine kinase activity of Activated FGFR1:FRS2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180901
displayName	Activated FGFR1 phosphorylates FRS2
eventOf	[Pathway:R-RNO-5654693] FRS-mediated FGFR1 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Rattus norvegicus [Reaction:R-RNO-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1 - Rattus norvegicus [Reaction:R-RNO-5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5654575] Activated FGFR1 phosphorylates FRS2 - Homo sapiens
input	[Complex:R-RNO-5654176] Activated FGFR1:FRS2 [plasma membrane] 6 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR1 phosphorylates FRS2
output	[Complex:R-RNO-5654200] Activated FGFR1:p-FRS2 [plasma membrane] 6 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-RNO-5654569] Activated FGFR1 binds FRS2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5654575
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5654693] FRS-mediated FGFR1 signaling
(precedingEvent)	[Reaction:R-RNO-5654584] Activated FGFR1:p-FRS bind to PPTN11 [Reaction:R-RNO-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1 [Reaction:R-RNO-5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
(inferredTo)	[Reaction:R-HSA-5654575] Activated FGFR1 phosphorylates FRS2