Reactome | Activated FGFR2 binds PLCG1

Schema > Reaction > Entries

Activated FGFR2 binds PLCG1 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180716
displayName	Activated FGFR2 binds PLCG1
eventOf	[Pathway:R-RNO-5654221] Phospholipase C-mediated cascade; FGFR2 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5654147] Activated FGFR2 phosphorylates PLCG1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5654159] Activated FGFR2 binds PLCG1 - Homo sapiens
input	[DefinedSet:R-RNO-5654152] Activated FGFR2 [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-167682] PLCG1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR2 binds PLCG1
output	[Complex:R-RNO-5654162] activated FGFR2:PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-RNO-190408] Autocatalytic phosphorylation of FGFR2b - Rattus norvegicus [Reaction:R-RNO-190413] Autocatalytic phosphorylation of FGFR2c - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5654159
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5654221] Phospholipase C-mediated cascade; FGFR2
(precedingEvent)	[Reaction:R-RNO-5654147] Activated FGFR2 phosphorylates PLCG1
(inferredTo)	[Reaction:R-HSA-5654159] Activated FGFR2 binds PLCG1