Reactome | LIG3 ligates NEIL1,NEIL2-generated single strand break

Schema > Reaction > Entries

LIG3 ligates NEIL1,NEIL2-generated single strand break Show undefined attributes

catalystActivity	[CatalystActivity:10180390] DNA ligase activity of NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180392
displayName	LIG3 ligates NEIL1,NEIL2-generated single strand break
eventOf	[Pathway:R-RNO-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5649734] LIG3 ligates NEIL1,NEIL2-generated single strand break - Homo sapiens
input	[Complex:R-RNO-5649733] NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	LIG3 ligates NEIL1,NEIL2-generated single strand break
output	[Complex:R-RNO-5649722] NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-RNO-5649723] POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5649734
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
(inferredTo)	[Reaction:R-HSA-5649734] LIG3 ligates NEIL1,NEIL2-generated single strand break

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