Reactome | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

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Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224725
displayName	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
eventOf	[Pathway:R-RNO-5625740] RHO GTPases activate PKNs - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:436782] regulation of androgen receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-5625717] Phosphorylated PKN1 binds androgen receptor (AR) - Rattus norvegicus [Reaction:R-RNO-5625738] p-T774-PKN1:AR:Androgen complex translocates to the nucleus - Rattus norvegicus [Reaction:R-RNO-5625745] PKN1 stimulates association of AR with NCOA2 - Rattus norvegicus [Reaction:R-RNO-5625774] PKN1:AR complex binds promoters of KLK2 and KLK3 genes - Rattus norvegicus [Reaction:R-RNO-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Rattus norvegicus [Reaction:R-RNO-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Rattus norvegicus [Reaction:R-RNO-5625797] KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters - Rattus norvegicus [Reaction:R-RNO-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Rattus norvegicus [Reaction:R-RNO-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Rattus norvegicus [Reaction:R-RNO-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5625886
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5625740] RHO GTPases activate PKNs
(inferredTo)	[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3