Reactome | CK1 phosphorylates p-GLI3

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CK1 phosphorylates p-GLI3 Show undefined attributes

catalystActivity	[CatalystActivity:10178168] protein serine/threonine kinase activity of CSNK1A1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10178170
displayName	CK1 phosphorylates p-GLI3
eventOf	[Pathway:R-RNO-5610785] GLI3 is processed to GLI3R by the proteasome - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5610732] GSK3 phosphorylates p-GLI3 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5610722] CK1 phosphorylates p-GLI3 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-5610595] p6S-GLI3:SUFU [ciliary base]
isInDisease	false
isInferred	true
maxDepth	1
name	CK1 phosphorylates p-GLI3
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-5610581] p10S-GLI3:SUFU [ciliary base]
precedingEvent	[Reaction:R-RNO-5610720] PKA phosphorylates GLI3 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5610722
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5610785] GLI3 is processed to GLI3R by the proteasome
(precedingEvent)	[Reaction:R-RNO-5610732] GSK3 phosphorylates p-GLI3
(inferredTo)	[Reaction:R-HSA-5610722] CK1 phosphorylates p-GLI3

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