Reactome | G3P is acylated to 1-acyl LPA by AGPAT6

Schema > Reaction > Entries

G3P is acylated to 1-acyl LPA by AGPAT6 Show undefined attributes

catalystActivity	[CatalystActivity:10143413] glycerol-3-phosphate O-acyltransferase activity of AGPAT6 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10143415
displayName	G3P is acylated to 1-acyl LPA by AGPAT6
eventOf	[Pathway:R-RNO-1483166] Synthesis of PA - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-549112] G3P is acylated to 1-acyl LPA by AGPAT6 - Homo sapiens
input	[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol] [SimpleEntity:R-ALL-76114] G3P [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	G3P is acylated to 1-acyl LPA by AGPAT6 glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [ER membrane-associated] Conversion of glycerol-3-phosphate to lysophosphatidic acid
output	[SimpleEntity:R-ALL-1500604] 1-acyl LPA [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-RNO-75887] Conversion of Glycerol to Glycerol-3-phosphate - Rattus norvegicus [Reaction:R-RNO-75889] DHAP is converted to G3P by GPD1/GPD1L - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-549112
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1483166] Synthesis of PA
(precedingEvent)	[Reaction:R-RNO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT)
(inferredTo)	[Reaction:R-HSA-549112] G3P is acylated to 1-acyl LPA by AGPAT6

Cite Us!