Reactome | CYP1A2 hydroxylates AFB1 to AFM1

Schema > Reaction > Entries

CYP1A2 hydroxylates AFB1 to AFM1 Show undefined attributes

catalystActivity	[CatalystActivity:10109994] monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10177550
displayName	CYP1A2 hydroxylates AFB1 to AFM1
eventOf	[Pathway:R-RNO-5423646] Aflatoxin activation and detoxification - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5423647] CYP2A13 oxidises AFM1 to AFM1E - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5423678] CYP1A2 hydroxylates AFB1 to AFM1 - Homo sapiens
input	[SimpleEntity:R-ALL-5423605] AFB1 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP1A2 hydroxylates AFB1 to AFM1
output	[SimpleEntity:R-ALL-5423629] AFM1 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5423678
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5423646] Aflatoxin activation and detoxification
(precedingEvent)	[Reaction:R-RNO-5423647] CYP2A13 oxidises AFM1 to AFM1E
(inferredTo)	[Reaction:R-HSA-5423678] CYP1A2 hydroxylates AFB1 to AFM1

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