Reactome | EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]

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EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10176760] 5'-3' exonuclease activity of EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[BlackBoxEvent:R-RNO-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10176757
displayName	EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
hasComponent	[OtherEntity:R-ALL-5358526] DNA containing 1-2 base mismatch and single-strand incision [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-5357514] Exo1 [nucleoplasm] [Complex:R-RNO-5357522] MLH1:PMS2 [nucleoplasm] [Complex:R-RNO-5358531] MSH2:MSH6:ATP [nucleoplasm] [Complex:R-RNO-68440] PCNA homotrimer [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5358633] EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] - Homo sapiens
maxDepth	3
name	EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision
producedByEvent	[Reaction:R-RNO-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5358633
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[BlackBoxEvent:R-RNO-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch
(physicalEntity)	[CatalystActivity:10176760] 5'-3' exonuclease activity of EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
(output)	[Reaction:R-RNO-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)
(inferredTo)	[Complex:R-HSA-5358633] EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]

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