Reactome | DVL2 is phosphorylated by PKC

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DVL2 is phosphorylated by PKC Show undefined attributes

catalystActivity	[CatalystActivity:10174249] calcium,diacylglycerol-dependent serine/threonine kinase activity of Activated Protein kinase C (alpha, beta, gamma isoforms) [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10174251
displayName	DVL2 is phosphorylated by PKC
eventOf	[Pathway:R-RNO-5099900] WNT5A-dependent internalization of FZD4 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5138433] p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5138432] DVL2 is phosphorylated by PKC - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-5138436] WNT5A:FZD4:DVL2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	DVL2 is phosphorylated by PKC
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-5138442] WNT5A:FZD4:p-DVL2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-5138441] WNT5A-FZD4 recruits DVL2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5138432
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5099900] WNT5A-dependent internalization of FZD4
(precedingEvent)	[Reaction:R-RNO-5138433] p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis
(inferredTo)	[Reaction:R-HSA-5138432] DVL2 is phosphorylated by PKC