Reactome | Phosphorylated SHC recruits GRB2:SOS1

Schema > Reaction > Entries

Phosphorylated SHC recruits GRB2:SOS1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10142289
displayName	Phosphorylated SHC recruits GRB2:SOS1
eventOf	[Pathway:R-RNO-912526] Interleukin receptor SHC signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5672965] RAS GEFs promote RAS nucleotide exchange - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-453111] Phosphorylated SHC recruits GRB2:SOS1 - Homo sapiens
input	4 × [Complex:R-RNO-109797] GRB2-1:SOS1 [cytosol] [DefinedSet:R-RNO-912534] Interleukin receptor complexes with activated SHC1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated SHC recruits GRB2:SOS1
output	[Complex:R-RNO-921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-RNO-109813] GRB2-1 binds SOS1 - Rattus norvegicus [Reaction:R-RNO-452100] SHC1 bound to IL2 receptor is phosphorylated - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-453111
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-912526] Interleukin receptor SHC signaling
(precedingEvent)	[Reaction:R-RNO-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-453111] Phosphorylated SHC recruits GRB2:SOS1

Cite Us!