Reactome | IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation

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IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10140863
displayName	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation
eventOf	[Pathway:R-RNO-9020702] Interleukin-1 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-446684] IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation - Homo sapiens
input	[Complex:R-RNO-446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] [EntityWithAccessionedSequence:R-RNO-772534] IRAK2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation
output	[EntityWithAccessionedSequence:R-RNO-446636] phospho-p-IRAK2 [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-446684
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9020702] Interleukin-1 signaling
(inferredTo)	[BlackBoxEvent:R-HSA-446684] IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation

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