Reactome | DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP

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DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP Show undefined attributes

catalystActivity	[CatalystActivity:10173215] transferase activity, transferring alkyl or aryl (other than methyl) groups of DHDDS:NUS1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10173217
displayName	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP
eventOf	[Pathway:R-RNO-446199] Synthesis of dolichyl-phosphate - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-4419978] DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP - Homo sapiens
input	[SimpleEntity:R-ALL-4419987] E,E-FPP [cytosol] 20 × [SimpleEntity:R-ALL-191362] IPPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate => a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate
output	20 × [SimpleEntity:R-ALL-111294] PPi [cytosol] [SimpleEntity:R-ALL-4419982] pPPP [cytoplasmic side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-RNO-191414] MVD decarboxylates MVA5PP to IPPP - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4419978
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-446199] Synthesis of dolichyl-phosphate
(inferredTo)	[Reaction:R-HSA-4419978] DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP

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