Reactome | ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A

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ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A Show undefined attributes

catalystActivity	[CatalystActivity:10139710] palmitoyl-CoA ligase activity of ACSL3,4 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10139712
displayName	ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A
eventOf	[Pathway:R-RNO-434313] Intracellular metabolism of fatty acids regulates insulin secretion - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-200406] CPT1A transfers PALM to CAR - Rattus norvegicus [Reaction:R-RNO-9911362] CPT1B transfers PALM to CAR - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-8876730] LCFA(-) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-164991] LCFA-CoA [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-RNO-434381] CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-434382
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-434313] Intracellular metabolism of fatty acids regulates insulin secretion
(precedingEvent)	[Reaction:R-RNO-200406] CPT1A transfers PALM to CAR [Reaction:R-RNO-9911362] CPT1B transfers PALM to CAR
(inferredTo)	[Reaction:R-HSA-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A

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