Reactome | trans-Golgi Network Lysosomal Vesicle Scission

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trans-Golgi Network Lysosomal Vesicle Scission Show undefined attributes

catalystActivity	[CatalystActivity:10139532] GTPase activity of Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10139534
displayName	trans-Golgi Network Lysosomal Vesicle Scission
eventOf	[Pathway:R-RNO-432720] Lysosome Vesicle Biogenesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-432688] trans-Golgi Network Derived Lysosomal Vesicle Uncoating - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-432707] trans-Golgi Network Lysosomal Vesicle Scission - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-RNO-432704] Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	trans-Golgi Network Lysosomal Vesicle Scission
output	[EntityWithAccessionedSequence:R-RNO-9619847] Dnm2 [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-RNO-432691] Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] [SimpleEntity:R-ALL-29372] Pi [cytosol] [EntityWithAccessionedSequence:R-RNO-182958] Sh3gl2 [cytosol]
precedingEvent	[Reaction:R-RNO-432706] trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-432707
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-432720] Lysosome Vesicle Biogenesis
(precedingEvent)	[Reaction:R-RNO-432688] trans-Golgi Network Derived Lysosomal Vesicle Uncoating
(inferredTo)	[Reaction:R-HSA-432707] trans-Golgi Network Lysosomal Vesicle Scission