Reactome | SLC4A1,2,3 exchanges HCO3- for Cl-

Schema > Reaction > Entries

SLC4A1,2,3 exchanges HCO3- for Cl- Show undefined attributes

catalystActivity	[CatalystActivity:10137887] solute:inorganic anion antiporter activity of SLC4A1,2,3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10137889
displayName	SLC4A1,2,3 exchanges HCO3- for Cl-
eventOf	[Pathway:R-RNO-425381] Bicarbonate transporters - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-425577] Na+-driven Cl-/HCO3- exchanger transport - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-425482] SLC4A1,2,3 exchanges HCO3- for Cl- - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-111627] HCO3- [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC4A1,2,3 exchanges HCO3- for Cl- Cl-/HCO3- exchanger transport
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-425425] HCO3- [extracellular region]
precedingEvent	[Reaction:R-RNO-425577] Na+-driven Cl-/HCO3- exchanger transport - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-425482
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-425381] Bicarbonate transporters
(precedingEvent)	[Reaction:R-RNO-425577] Na+-driven Cl-/HCO3- exchanger transport
(inferredTo)	[Reaction:R-HSA-425482] SLC4A1,2,3 exchanges HCO3- for Cl-

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