Reactome | Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity

Schema > Reaction > Entries

Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity Show undefined attributes

catalystActivity	[CatalystActivity:10136375] GTPase activator activity of SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10136377
displayName	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
eventOf	[Pathway:R-RNO-416550] Sema4D mediated inhibition of cell attachment and migration - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-416546] Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity - Homo sapiens
input	[Complex:R-RNO-399865] R-Ras-GTP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-RNO-399866] R-Ras-GDP [plasma membrane]
precedingEvent	[Reaction:R-RNO-400677] Rnd1 interacts with Plexin-B1:Sema4D - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-416546
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-416550] Sema4D mediated inhibition of cell attachment and migration
(inferredTo)	[Reaction:R-HSA-416546] Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity

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