Reactome | NANS converts ManNAc-6-P to Neu5Ac-9-P

Schema > Reaction > Entries

NANS converts ManNAc-6-P to Neu5Ac-9-P Show undefined attributes

catalystActivity	[CatalystActivity:10172565] N-acylneuraminate-9-phosphate synthase activity of NANS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10172567
displayName	NANS converts ManNAc-6-P to Neu5Ac-9-P
eventOf	[Pathway:R-RNO-4085001] Sialic acid metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-4084989] NANP dephosphorylates Neu5Ac-9-P to Neu5Ac - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-4084976] NANS converts ManNAc-6-P to Neu5Ac-9-P - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-4085225] ManNAc-6-P [cytosol] [SimpleEntity:R-ALL-29492] PEP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NANS converts ManNAc-6-P to Neu5Ac-9-P aldehydo-N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O => N-acetylneuraminate 9-phosphate + phosphate
output	[SimpleEntity:R-ALL-4085390] Neu5Ac-9-P [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-RNO-4085028] GNE phosphorylates ManNAc to ManNAc-6-P - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4084976
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4085001] Sialic acid metabolism
(precedingEvent)	[Reaction:R-RNO-4084989] NANP dephosphorylates Neu5Ac-9-P to Neu5Ac
(inferredTo)	[Reaction:R-HSA-4084976] NANS converts ManNAc-6-P to Neu5Ac-9-P

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