Reactome | p-4Y-SIRPA:CD47 binds GRB2-1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10135384
displayName	p-4Y-SIRPA:CD47 binds GRB2-1
eventOf	[Pathway:R-RNO-391160] Signal regulatory protein family interactions - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-391153] p-4Y-SIRPA:CD47 binds GRB2-1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-74686] Grb2 [cytosol] [Complex:R-RNO-391115] p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-4Y-SIRPA:CD47 binds GRB2-1 Recruitment of Grb2 to pSIRP alpha
output	[Complex:R-RNO-391112] p-Y428,Y452,Y469,Y495-SIRPA:CD47:GRB2-1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-391153
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-391160] Signal regulatory protein family interactions
(inferredTo)	[Reaction:R-HSA-391153] p-4Y-SIRPA:CD47 binds GRB2-1

Cite Us!