Reactome | POMC(138-176) binds MC2R

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10134465
displayName	POMC(138-176) binds MC2R
eventOf	[Pathway:R-RNO-375276] Peptide ligand-binding receptors - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-388605] POMC(138-176) binds MC2R - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-388600] MC2R [plasma membrane] [EntityWithAccessionedSequence:R-RNO-388607] Pomc [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	POMC(138-176) binds MC2R ACTH binds MC2R
output	[Complex:R-RNO-388603] POMC(138-176):MC2R [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-388605
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-375276] Peptide ligand-binding receptors
(inferredTo)	[Reaction:R-HSA-388605] POMC(138-176) binds MC2R

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