Reactome | Apelin receptor binds to apelin

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10130753
displayName	Apelin receptor binds to apelin
eventOf	[Pathway:R-RNO-375276] Peptide ligand-binding receptors - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-374337] Apelin receptor binds to apelin - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-374315] Apln [extracellular region] [EntityWithAccessionedSequence:R-RNO-374259] Aplnr [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Apelin receptor binds to apelin
output	[Complex:R-RNO-374316] APLNR:Apelin peptides [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-374337
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-375276] Peptide ligand-binding receptors
(inferredTo)	[Reaction:R-HSA-374337] Apelin receptor binds to apelin

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