Reactome | TBK1 is phosphorylated within STING:TBK1:STAT6 complex

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TBK1 is phosphorylated within STING:TBK1:STAT6 complex Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10170068
displayName	TBK1 is phosphorylated within STING:TBK1:STAT6 complex
eventOf	[Pathway:R-RNO-3249367] STAT6-mediated induction of chemokines - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-3249371] TBK1 phosphorylates STAT6 at Ser407 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3249390] TBK1 is phosphorylated within STING:TBK1:STAT6 complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-3249399] STING:TBK1:STAT6 [cytoplasmic vesicle membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TBK1 is phosphorylated within STING:TBK1:STAT6 complex
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-3249391] STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane]
precedingEvent	[Reaction:R-RNO-3249378] STING recruits TBK1 and STAT6 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3249390
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3249367] STAT6-mediated induction of chemokines
(precedingEvent)	[Reaction:R-RNO-3249371] TBK1 phosphorylates STAT6 at Ser407
(inferredTo)	[Reaction:R-HSA-3249390] TBK1 is phosphorylated within STING:TBK1:STAT6 complex

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