Reactome | p-S407-STAT6 is phosphorylated at Tyr641

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p-S407-STAT6 is phosphorylated at Tyr641 Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10170066
displayName	p-S407-STAT6 is phosphorylated at Tyr641
eventOf	[Pathway:R-RNO-3249367] STAT6-mediated induction of chemokines - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-3249372] p-S407,Y641-STAT6 is dimerized - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3249379] p-S407-STAT6 is phosphorylated at Tyr641 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-RNO-3249369] phospho-Stat6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-S407-STAT6 is phosphorylated at Tyr641
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-3249376] phospho-Stat6 [cytosol]
precedingEvent	[Reaction:R-RNO-3249371] TBK1 phosphorylates STAT6 at Ser407 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3249379
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3249367] STAT6-mediated induction of chemokines
(precedingEvent)	[Reaction:R-RNO-3249372] p-S407,Y641-STAT6 is dimerized
(inferredTo)	[Reaction:R-HSA-3249379] p-S407-STAT6 is phosphorylated at Tyr641

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