Reactome | STING binds cyclic GMP-AMP

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STING binds cyclic GMP-AMP Show undefined attributes

category	omitted
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10169687
displayName	STING binds cyclic GMP-AMP
eventOf	[Pathway:R-RNO-1834941] STING mediated induction of host immune responses - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-3244643] STING binds cyclic GMP-AMP - Homo sapiens
input	[SimpleEntity:R-ALL-3244587] c-GMP-AMP [cytosol] [Complex:R-RNO-2395989] STING:STING [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	STING binds cyclic GMP-AMP
output	[Complex:R-RNO-3244600] STING:cGAMP [cytoplasmic vesicle membrane]
precedingEvent	[Reaction:R-RNO-3134800] STING dimerization - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3244643
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1834941] STING mediated induction of host immune responses
(inferredTo)	[BlackBoxEvent:R-HSA-3244643] STING binds cyclic GMP-AMP