Reactome | PIAS1,4 SUMOylates BRCA1 with SUMO2,3

Schema > Reaction > Entries

PIAS1,4 SUMOylates BRCA1 with SUMO2,3 Show undefined attributes

catalystActivity	[CatalystActivity:10168743] SUMO transferase activity of PIAS1,4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10168745
displayName	PIAS1,4 SUMOylates BRCA1 with SUMO2,3
eventOf	[Pathway:R-RNO-3108214] SUMOylation of DNA damage response and repair proteins - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2997616] PIAS1,4 SUMOylates BRCA1 with SUMO2,3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-50949] Brca1 [nucleoplasm] 2 × [DefinedSet:R-RNO-3899312] UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PIAS1,4 SUMOylates BRCA1 with SUMO2,3 Conjugation of SUMO2,3 to BRCA1
output	[EntityWithAccessionedSequence:R-RNO-2997624] Brca1 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-RNO-912481] Ube2i [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2997616
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3108214] SUMOylation of DNA damage response and repair proteins
(inferredTo)	[Reaction:R-HSA-2997616] PIAS1,4 SUMOylates BRCA1 with SUMO2,3

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