Reactome | GGT1, 5 dimers hydrolyse LTC4 to LTD4

Schema > Reaction > Entries

GGT1, 5 dimers hydrolyse LTC4 to LTD4 Show undefined attributes

catalystActivity	[CatalystActivity:10129361] glutathione gamma-glutamate hydrolase activity of GGT1, 5 dimers [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10129363
displayName	GGT1, 5 dimers hydrolyse LTC4 to LTD4
eventOf	[Pathway:R-RNO-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-266046] GGT1, 5 dimers hydrolyse LTC4 to LTD4 - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-266013] LTC4 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	GGT1, 5 dimers hydrolyse LTC4 to LTD4 H2O + leukotriene C4 => L-glutamate + leukotriene D4 Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4
output	[SimpleEntity:R-ALL-210382] L-Glu [extracellular region] [SimpleEntity:R-ALL-266074] LTD4 [extracellular region]
precedingEvent	[Reaction:R-RNO-266070] LTC4 is exported from the cytosol by ABCC1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-266046
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(inferredTo)	[Reaction:R-HSA-266046] GGT1, 5 dimers hydrolyse LTC4 to LTD4

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